Genetic Model for the Rh Blood-Group System

THE Rh BLOOD GROUP SYSTEM

T he Rh blood group system is one of the most polymorphic and antigenic blood group systems. It is second only to ABO in importance in blood transfusion and is well known as a primary cause of hemolytic disease of the fetus and newborn (HDFN). The principal antigen is D, and the terms Rh positive and Rh negative refer to the presence or absence of D antigen. Caucasians of European extraction ha...

The Rh blood group system: a review

The Rh blood group system is one of the most polymorphic and immunogenic systems known in humans. In the past decade, intense investigation has yielded considerable knowledge of the molecular background of this system. The genes encoding 2 distinct Rh proteins that carry C or c together with either E or e antigens, and the D antigen, have been cloned, and the molecular bases of many of the anti...

Molecular-genetic variance of RH blood group system within human population of Bosnia and Herzegovina.

There are two major theories for inheritance of Rh blood group system: Fisher - Race theory and Wiener theory. Aim of this study was identifying frequency of RHDCE alleles in Bosnian - Herzegovinian population and introduction of this method in screening for Rh phenotype in B&H since this type of analysis was not used for blood typing in B&H before. Rh blood group was typed by Polymerase Chain ...

The Rh blood group system in review: a new face for the next decade.

h is the most well-recognized blood group system after ABO, probably because of the dramatic presentation of a fetus suffering hemolytic disease of the newborn (HDN) following maternal alloimmunization to the D antigen. Even individuals not associated with medicine have heard of the “Rh factor” and are aware that it has some importance in pregnancy. The earliest recorded description of the synd...

Some observations on blood factors RhA, RhB and RhC of the Rh-Hr blood group system.